Homologue-specific chromosome sequencing characterizes translocation junctions and permits allelic assignment
نویسندگان
چکیده
منابع مشابه
Allelic loss at chromosome 3p characterizes clear cell phenotype of renal cell carcinoma.
Incidence of the loss of heterozygosity on chromosome 3p was evaluated using 7 polymorphic probes in 35 Japanese patients with sporadic renal cell carcinoma (RCC). Overall frequency of the loss of heterozygosity on 3p was 53%, representing 16 of 30 informative cases. Examination of the relationship between histopathological phenotypes of RCC and incidence of the 3p loss revealed that the loss o...
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Whereas chromosomal translocations are common pathogenetic events in cancer, mechanisms that promote them are poorly understood. To elucidate translocation mechanisms in mammalian cells, we developed high-throughput, genome-wide translocation sequencing (HTGTS). We employed HTGTS to identify tens of thousands of independent translocation junctions involving fixed I-SceI meganuclease-generated D...
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ژورنال
عنوان ژورنال: DNA Research
سال: 2018
ISSN: 1340-2838,1756-1663
DOI: 10.1093/dnares/dsy007